Genetics of latent autoimmune diabetes in adults.

Abstract

Slowly progressive insulin-dependent diabetes mellitus (IDDM), like classical IDDM, is also associated with genetic markers. HLA-DR3 but not DR4 is associated with latent autoimmune diabetes in adults (LADA). In GAD65 antibody-positive Finnish LADA patients, DQB1*0302 is positively associated with the disease. Alleles of the MHC class I chain-related A (MICA) gene located centromeric to the HLA-B gene is associated with LADA. Allele 5.1 of MICA was associated with both LADA and adult-onset Italian IDDM patients when compared to controls. This finding was also observed in Indian and Latvian patients with LADA. These findings suggest that certain genetic markers distinguish LADA better.

• Authors: C B Sanjeevi, G Gambelunghe, A Falorni, A Shtauvere-Brameus, A Kanungo
• Journal: Annals of the New York Academy of Sciences (Ann N Y Acad Sci) Vol. 958 Pg. 107-11 (Apr 2002) ISSN: 0077-8923 [Print] United States
• PMID: 12021089 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA Antigens
• Histocompatibility Antigens Class I
• MHC class I-related chain A

Topics

• Adult
• Age of Onset
• Alleles
• Diabetes Mellitus, Type 1 (ethnology, genetics)
• Ethnicity (genetics)
• Genetic Predisposition to Disease (genetics)
• HLA Antigens (genetics)
• Histocompatibility Antigens Class I (genetics)
• Humans