Abstract |
Biosearch Italia and Versicor are developing dalbavancin, a novel semisynthetic derivative of the natural glycopeptide A-40926 for the potential treatment of Gram-positive infections. In May 2001, the compound entered phase II trials in the US [409929], [409932]. As of Janaury 2002, phase II trials in skin infections and bacteremia were ongoing [436430]. Both dalbavancin and MDL-63246 are dimethylaminopropyl amide derivatives of A-40926; dalbavancin differs from MDL-63246 in its acylamino sugar, which consists of glucuronic acid in dalbavancin and glucosamine in MDL-63246 [216093], [298527]. The development of MDL-63246 has been discontinued [298527]. In January 1999, Versicor gained North American market rights to BI-397 [311500]. In January 2002, UBS Warburg predicted filing of an NDA in the second half of 2003 for dalbavancin, for treatment of complicated skin and soft tissue infections [439472]. In December 2001, Lehman Brothers predicted a late 2005 launch for dalbavancin, with sales of US $7.7 million in 2005, US $65.8 million in 2006, and peak sales of US $225 million in 2008 [439469].
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Authors | Matthias Steiert, Franz-Josef Schmitz |
Journal | Current opinion in investigational drugs (London, England : 2000)
(Curr Opin Investig Drugs)
Vol. 3
Issue 2
Pg. 229-33
(Feb 2002)
ISSN: 1472-4472 [Print] England |
PMID | 12020051
(Publication Type: Journal Article, Review)
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Chemical References |
- Anti-Infective Agents
- Drugs, Investigational
- Glycopeptides
- Teicoplanin
- dalbavancin
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Topics |
- Anti-Infective Agents
(pharmacokinetics, pharmacology, therapeutic use)
- Biological Availability
- Clinical Trials, Phase I as Topic
- Clinical Trials, Phase II as Topic
- Dermatitis
(drug therapy)
- Drug Industry
- Drugs, Investigational
(pharmacokinetics, pharmacology, therapeutic use)
- Glycopeptides
(pharmacokinetics, pharmacology, therapeutic use)
- Gram-Positive Bacterial Infections
(drug therapy)
- Humans
- Microbial Sensitivity Tests
- Structure-Activity Relationship
- Teicoplanin
(analogs & derivatives)
- Treatment Outcome
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