Impact of N-chlorotaurine on viability and production of secreted aspartyl proteinases of Candida spp.

Abstract

N-Chlorotaurine, an endogenous long-lived oxidant, demonstrated fungicidal activity against Candida spp. and a postantifungal effect. Secreted aspartyl proteinases, important fungal virulence factors, proved to be a first target of impact. These results provide support for the topical application of N-chlorotaurine as an antimicrobial agent in yeast infections.

• Authors: Markus Nagl, Andreas Gruber, Anita Fuchs, Claudia P Lell, Eva-Maria Lemberger, Margarete Borg-Von Zepelin, Reinhard Würzner
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 46 Issue 6 Pg. 1996-9 (Jun 2002) ISSN: 0066-4804 [Print] United States
• PMID: 12019124 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Protease Inhibitors
• Taurine
• N-chlorotaurine
• Aspartic Acid Endopeptidases

Topics

• Aspartic Acid Endopeptidases (antagonists & inhibitors)
• Candida (drug effects, enzymology, growth & development)
• Microbial Sensitivity Tests
• Protease Inhibitors (pharmacology)
• Taurine (analogs & derivatives, pharmacology)