Helicobacter pylori infection increases serum nitrate and nitrite more prominently than serum pepsinogens.

Abstract

BACKGROUND:

Helicobacter pylori infection causes chronic gastritis and results in increased serum concentrations of pepsinogens I and II as well as gastrin, while the ratio of pepsinogen I to II (I : II) is decreased. Inducible nitric oxide synthase (iNOS) is induced in H. pylori-associated gastritis and may modulate inflammation. However serum nitrate and nitrite (NOx) concentrations in patients with H. pylori-induced chronic gastritis have not been reported. We examined differences in serum NOx between H. pylori-negative and positive volunteers relative to differences in pepsinogens and gastrin.

MATERIALS AND METHODS:

Sera from 80 healthy asymptomatic volunteers younger than 36 years were analyzed for anti-H. pylori antibody, NOx, gastrin and pepsinogens.

RESULTS:

In H. pylori antibody-positive subjects serum NOx concentrations were higher than in negative subjects (p < .005). In H. pylori-negative subjects, NOx correlated with pepsinogen II (r = .405, p < .05). In subjects with low pepsinogen I or II, NOx was higher in H. pylori-positive than negative subjects (p < .001). In subjects with high pepsinogen I : II (6 or higher), serum NOx was higher in H. pylori-positive than in negative subjects.

CONCLUSIONS:

H. pylori-induced gastritis increases serum NOx concentrations more prominently than those of pepsinogen. In H. pylori-negative subjects, serum correlates with serum pepsinogen II.

• Authors: Kanji Kodama, Koji Sumii, Masanori Kawano, Tamako Kido, Keiko Nojima, Masaharu Sumii, Ken Haruma, Masaharu Yoshihara, Kazuaki Chayama
• Journal: Helicobacter (Helicobacter) Vol. 7 Issue 1 Pg. 9-13 (Feb 2002) ISSN: 1083-4389 [Print] England
• PMID: 12017117 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Gastrins
• Nitrates
• Nitrites
• Pepsinogen A

Topics

• Adult
• Female
• Gastrins (blood)
• Helicobacter Infections (blood)
• Helicobacter pylori
• Humans
• Male
• Nitrates (blood)
• Nitrites (blood)
• Pepsinogen A (blood)