Heart failure accompanied by sick euthyroid syndrome and exercise training.

Abstract

Sick euthyroid syndrome is defined as the decrease of serum free triiodothyronine with normal free L-thyroxin and thyrotropin. Its appearance in patients with chronic heart failure is an indicator of severity. Exercise training through a wide variety of mechanisms reverses sick euthyroid syndrome (normalization of free triiodothyronine levels) and improves the ability to exercise. There is a connection during exercise among dyspnea, hyperventilation, fatigue, catecholamines, a decrease in the number and function of beta-blocker receptors, and elevation of serum free triiodothyronine. It is not known whether sick euthyroid syndrome contributes to the development of heart failure or is only an attendant syndrome.

• Authors: D Psirropoulos, N Lefkos, G Boudonas, A Efthimiadis, V Vogas, C Keskilidis, G Tsapas
• Journal: Current opinion in cardiology (Curr Opin Cardiol) Vol. 17 Issue 3 Pg. 266-70 (May 2002) ISSN: 0268-4705 [Print] United States
• PMID: 12015476 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Triiodothyronine
• Thyrotropin
• Thyroxine

Topics

• Aged
• Atrial Function, Left (physiology)
• Euthyroid Sick Syndromes (blood, complications, therapy)
• Exercise Test
• Exercise Therapy
• Female
• Heart Failure (blood, physiopathology, therapy)
• Humans
• Male
• Middle Aged
• Severity of Illness Index
• Stroke Volume (physiology)
• Thyrotropin (blood)
• Thyroxine (blood)
• Treatment Outcome
• Triiodothyronine (blood)
• Ventricular Function, Left (physiology)