Abstract |
Buprenorphine is an effective treatment for heroin dependence. The feasibility and potential efficacy of buprenorphine with brief counseling in primary care is unknown. We enrolled 14 heroin dependent patients in a 13-week clinical trial using thrice weekly buprenorphine along with brief counseling in the primary care center of an urban medical center. Primary outcomes included urine toxicology and treatment retention. Opioid-positive urine toxicology tests reduced over the 13-week period from 95 to 25% (p < 0.05). Eleven patients (79%) had greater than or equal to one week of opioid-free urine toxicologies. Nine patients (64%) had greater than or equal to three weeks of opioid-free urine toxicologies. Eleven patients (79%) were retained through the maintenance phase. We conclude that buprenorphine maintenance is feasible in a primary care setting.
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Authors | David A Fiellin, Michael V Pantalon, Juliana P Pakes, Patrick G O'Connor, Marek Chawarski, Richard S Schottenfeld |
Journal | The American journal of drug and alcohol abuse
(Am J Drug Alcohol Abuse)
Vol. 28
Issue 2
Pg. 231-41
( 2002)
ISSN: 0095-2990 [Print] England |
PMID | 12014814
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Administration, Sublingual
- Adult
- Ambulatory Care
- Buprenorphine
(administration & dosage, adverse effects)
- Combined Modality Therapy
- Connecticut
- Counseling
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Feasibility Studies
- Female
- Heroin Dependence
(rehabilitation)
- Humans
- Male
- Middle Aged
- Primary Health Care
- Social Support
- Treatment Outcome
- Urban Population
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