Treatment of severe cholestasis in neonatal Dubin-Johnson syndrome with ursodeoxycholic acid.

Abstract

We report a case of Dubin-Johnson Syndrome in a neonate presenting with severe direct hyperbilirubinemia, which failed to respond to phenobarbital treatment. Ursodeoxycholic Acid added to therapy was well tolerated, and resulted in declining bilirubin concentration. We suggest ursodeoxycholic acid in treatment for Dubin-Johnson Syndrome with severe direct hyperbilirubinemia presenting in the neonatal age.

• Authors: Rivka H Regev, Orit Stolar, Aryeh Raz, Tzipora Dolfin
• Journal: Journal of perinatal medicine (J Perinat Med) Vol. 30 Issue 2 Pg. 185-7 ( 2002) ISSN: 0300-5577 [Print] Germany
• PMID: 12012642 (Publication Type: Case Reports, Journal Article)

Chemical References

• Ursodeoxycholic Acid
• Bilirubin

Topics

• Bilirubin (blood)
• Cholestasis (drug therapy, etiology)
• Humans
• Hyperbilirubinemia (etiology)
• Infant, Newborn
• Jaundice, Chronic Idiopathic (complications, diagnosis)
• Male
• Ursodeoxycholic Acid (therapeutic use)