Both transferrin binding proteins are virulence factors in Actinobacillus pleuropneumoniae serotype 7 infection.

Abstract

Three genetically defined Actinobacillus pleuropneumoniae serotype 7 mutants with deletions in the small (tbpB), the large (tbpA), and both transferrin binding protein genes were constructed and examined in an aerosol infection model. Neither mutant caused clinical disease or could be reisolated, and no immune response could be detected 21 days after infection. This result clearly implies that each transferrin binding protein on its own is a virulence factor of A. pleuropneumoniae serotype 7.

• Authors: Nina Baltes, Isabel Hennig-Pauka, Gerald-F Gerlach
• Journal: FEMS microbiology letters (FEMS Microbiol Lett) Vol. 209 Issue 2 Pg. 283-7 (Apr 09 2002) ISSN: 0378-1097 [Print] England
• PMID: 12007819 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Aerosols
• Carrier Proteins
• Iron-Binding Proteins
• Transferrin-Binding Proteins

Topics

• Actinobacillus Infections (microbiology, veterinary)
• Actinobacillus pleuropneumoniae (classification, genetics, pathogenicity)
• Aerosols
• Animals
• Carrier Proteins (genetics, metabolism)
• Gene Deletion
• Iron-Binding Proteins
• Serotyping
• Swine
• Swine Diseases (microbiology)
• Transferrin-Binding Proteins
• Virulence