[Usefulness of scintigraphy images with 111In-CYT-103 in the diagnosis of colonic and rectal recurrence].

Abstract

OBJECTIVE:

To determine the effectiveness of radioimmunoscintigraphy (RIC) with 111In-CYT-103 in detecting the extension of malignant disease in patients surgically treated for colorectal adenocarcinoma under suspicion of recurrence in comparison to CT scan (computed tomography) and exploratory laparotomy.

DESIGN:

Prospective and observational study.

MATERIAL AND METHODS:

A total of 26 patients under suspicion of recurrence, with a total of 31 lesions. All the patients had performed the following studies with GT, RIC with 111In-CYT-103, exploratory laparotomy and histopathology.

RESULTS:

A sensitivity of 96.8%, and specificity of 77.8%, and accuracy of 92% were found for the RIC. CT scan had a sensitivity, specificity and accuracy of 71.5%, 88.8%, and 75.7%, respectively in extrahepatic lesions. When both methods are combined, results shows an increment in sensitivity. Hepatic lesions were present in 50% of the patients; a sensitivity of 85%, a specificity of 92%, and accuracy of 89% for RIC and sensitivity, specificity and accuracy of 92% for the CT.

CONCLUSION:

The results of clinical studies with 111In-CYT-103 in detecting the occurrence of colorectal carcinoma provided additional information, making this method a valuable complementary test that contributes to patient management.

• Authors: Rosalba García-Fernández, Pedro Luna-Pérez, Dulce María Hernández-Hernández, Laura Iwasaki-Otake, Pablo Pichardo-Romero, Saúl Rodríguez-Ramirez
• Journal: Gaceta medica de Mexico (Gac Med Mex) 2002 Mar-Apr Vol. 138 Issue 2 Pg. 139-44 ISSN: 0016-3813 [Print] Mexico
• Vernacular Title: Utilidad de las imágenes centelleográficas con 111In.CYT-103 en el diagnóstico de recurrencia del cáncer de colon y recto.
• PMID: 12001423 (Publication Type: Journal Article)

Chemical References

• Antibodies, Monoclonal
• Indium 111In-satumomab pendetide
• Oligopeptides
• Pentetic Acid

Topics

• Adenocarcinoma (diagnostic imaging, secondary)
• Antibodies, Monoclonal
• Colorectal Neoplasms (diagnostic imaging, pathology)
• Female
• Humans
• Male
• Middle Aged
• Neoplasm Metastasis
• Neoplasm Recurrence, Local (diagnostic imaging)
• Oligopeptides
• Pentetic Acid (analogs & derivatives)
• Prospective Studies
• Radionuclide Imaging
• Sensitivity and Specificity