Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder.

Abstract	Various types of evidence implicate nitric oxide and an oxidant, possibly peroxynitrite, in MCS and chemical intolerance (CI). The positive feedback loops proposed earlier for CFS may explain the chronic nature of MCS (CI) as well as several of its other reported properties. These observations raise the possibility that this proposed elevated nitric oxide/peroxynitrite mechanism may be the mechanism of a new disease paradigm, answering the question raised by Miller earlier: "Are we on the threshold of a new theory of disease?"
Authors	M L Pall, J D Satterlee
Journal	Annals of the New York Academy of Sciences (Ann N Y Acad Sci) Vol. 933 Pg. 323-9 (Mar 2001) ISSN: 0077-8923 [Print] United States
PMID	12000033 (Publication Type: Comparative Study, Journal Article, Review)
Chemical References	Cholinesterase Inhibitors Cytokines Enzyme Inhibitors Insecticides Organophosphorus Compounds Receptors, Muscarinic Xenobiotics Peroxynitrous Acid Nitric Oxide Neopterin Arginine NOS2 protein, human Nitric Oxide Synthase Nitric Oxide Synthase Type II
Topics	Animals Arginine (biosynthesis) Blood-Brain Barrier (drug effects) Cholinesterase Inhibitors (adverse effects, pharmacology) Cytokines (metabolism) Enzyme Induction (drug effects) Enzyme Inhibitors (pharmacology) Fatigue Syndrome, Chronic (etiology, metabolism) Feedback Humans Inflammation (chemically induced, physiopathology) Insecticides (adverse effects, pharmacology) Kindling, Neurologic (drug effects) Models, Animal Models, Biological Multiple Chemical Sensitivity (etiology, metabolism) Neopterin (biosynthesis) Nitric Oxide (physiology) Nitric Oxide Synthase (antagonists & inhibitors, metabolism) Nitric Oxide Synthase Type II Organophosphorus Compounds Oxidation-Reduction Oxidative Stress Peroxynitrous Acid (physiology) Receptors, Muscarinic (biosynthesis, physiology) Stress Disorders, Post-Traumatic (etiology, metabolism) Up-Regulation (drug effects) Xenobiotics (adverse effects, pharmacology)

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