Abstract |
Although interleukin-2 (IL-2) and -15 (IL-15) share two receptor subunits and many functions, at times they provide contrasting contributions to T-cell-mediated immune responses. IL-2, through its pivitol role in activation-induced cell death (AICD), is involved in peripheral tolerance through the elimination of self-reactive T cells. In contrast, in general IL-15 manifests antiapoptotic actions and inhibits IL-2-mediated AICD. IL-15 stimulates persistence of memory phenotype CD8+ T cells, whereas IL-2 inhibits their expression. Humanized monoclonal antibodies that recognize IL-2Ra, the private receptor for IL-2, are being employed to inhibit allograft rejection and to treat T-cell leukemia/ lymphoma. Therapies directed toward inhibiting the actions of the inflammatory cytokine, IL-15, are proposed for an array of autoimmune disorders as well as diseases associated with the retrovirus human T-cell lymphotrophic virus 1.
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Authors | Thomas A Waldmann |
Journal | Journal of clinical immunology
(J Clin Immunol)
Vol. 22
Issue 2
Pg. 51-6
(Mar 2002)
ISSN: 0271-9142 [Print] Netherlands |
PMID | 11998892
(Publication Type: Journal Article, Review)
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Chemical References |
- Antibodies, Monoclonal
- IL15RA protein, human
- Interleukin-15
- Interleukin-2
- Receptors, Interleukin-15
- Receptors, Interleukin-2
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Topics |
- Animals
- Antibodies, Monoclonal
(therapeutic use)
- Autoimmune Diseases
(therapy)
- Humans
- Immunotherapy
- Interleukin-15
(immunology, metabolism)
- Interleukin-2
(immunology, metabolism)
- Receptors, Interleukin-15
- Receptors, Interleukin-2
(immunology, metabolism)
- T-Lymphocytes
(immunology)
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