Tuberoside M, a new cytotoxic spirostanol saponin from the seeds of Allium tuberosum.

Abstract

Tuberoside M (1), isolated from the seeds of Allium tuberosum, shows a significant inhibitory effect on the growth of the human promyelocytic leukemia cell line (HL-60) with IC50 value of 6.8 microg/ml. On the basis of spectral data and chemical reaction, its structure was established as (25S)-5beta-spirostane-1beta,3beta-diol 3-O-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranoside.

• Authors: Sheng-Min Sang, Min-Liang Zou, Xiong-Wen Zhang, Ai-Na Lao, Zhong-Liang Chen
• Journal: Journal of Asian natural products research (J Asian Nat Prod Res) Vol. 4 Issue 1 Pg. 69-72 (Mar 2002) ISSN: 1028-6020 [Print] England
• PMID: 11995668 (Publication Type: Journal Article)

Chemical References

• Saponins
• tuberoside M

Topics

• Allium (chemistry)
• Leukemia, Promyelocytic, Acute (pathology)
• Molecular Structure
• Saponins (chemistry, isolation & purification, pharmacology)
• Seeds (chemistry)
• Spectrum Analysis
• Toxicity Tests
• Tumor Cells, Cultured