Abstract | RATIONALE AND OBJECTIVES: MATERIALS AND METHODS: The time course of liver enhancement was determined in five groups of two normal anesthetized rabbits, which received intravenous injections of Dy-EOB-DTPA before anesthesia at a dose of 0.5 mmol/kg. Fifteen, 30, 45, 60, and 90 minutes after administration spiral CT images were obtained and the attenuation in the livers were determined. A second group of ten rabbits with implanted VX2 tumors received in a random crossover design either Dy-EOB-DTPA at a dose of 0.5 mmol/kg or, 1 day later, iopromide at a dose of 600 mg iodine/kg. CT images were obtained 60 minutes after Dy-EOB-DTPA administration and both in the arterial and portal-venous phases after iopromide injection. Three radiologists evaluated the images. The rabbits were killed, and their livers were investigated histologically for liver tumors. RESULTS: In normal animals, 0.5 mmol/kg Dy-EOB-DTPA resulted in a liver enhancement of 30 HU during the whole observation period of 90 minutes. In tumor-bearing animals, histology revealed 14 implanted tumors of 3-20 mm diameter. Sixty-five percent of the tumors were below 10 mm. Dy-EOB-DTPA was able to detect 13 tumors (93%), iopromide 11 (79%) both in the arterial and in the portal-venous phase. The difference was statistically not significant. In plain CT, seven tumors (50%) were found (P < 0.01 vs iopromide and Dy-EOB-DTPA). One scar and two sites of necrosis were detected by each of the methods. CONCLUSION:
Dy-EOB-DTPA injection at a dose of 0.5 mmol/kg resulted in a long-lasting detectability of 93% of all implanted tumors versus 79% found with iopromide.
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Authors | Werner Krause, Kerstin Handreke, G Schuhmann-Giampieri, K Rupp |
Journal | Investigative radiology
(Invest Radiol)
Vol. 37
Issue 5
Pg. 241-7
(May 2002)
ISSN: 0020-9996 [Print] United States |
PMID | 11979149
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Contrast Media
- dysprosium ethoxybenzyl DTPA
- Iohexol
- iopromide
- Pentetic Acid
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Topics |
- Animals
- Contrast Media
(administration & dosage, pharmacokinetics)
- Injections, Intravenous
- Iohexol
(administration & dosage, analogs & derivatives)
- Liver
(diagnostic imaging, metabolism)
- Liver Neoplasms, Experimental
(diagnostic imaging, metabolism, pathology)
- Molecular Structure
- Pentetic Acid
(administration & dosage, analogs & derivatives, chemistry, pharmacokinetics)
- Rabbits
- Time Factors
- Tomography, X-Ray Computed
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