The ectopic expression of gastric mucin in extramammary and mammary Paget's disease.
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| Abstract |
The immunohistochemical analysis of the ectopic expression of gastric mucin has been used as a valuable tool for the identification of several neoplasms. We performed an immunohistochemical examination of the expression of gastric, intestinal, and mammary-type mucins in 25 lesions from patients with extramammary Paget's disease (ExMPD) and in 10 lesions from patients with mammary Paget's disease (MPD). All ExMPD lesions were immunopositive for HGM-45, a marker of gastric surface mucous cells, whereas only 40% of MPD lesions were weakly immunopositive. No markers for gastric-gland mucous cells were found in almost all ExMPD and MPD lesions, and markers for intestinal mucin were recognized in only a few lesions. Antibodies specific for MUC1, a marker of mammary-type mucin, gave positive results in both ExMPD and MPD lesions at a higher frequency than antibodies specific for gross cystic disease fluid protein-15. Our analysis indicates that Paget's cells contain gastric surface-type mucin in ExMPD and they contain mammary-type mucin in both ExMPD and MPD. The ectopic localization of mucosubstances may be a further step in the understanding of these lesions. Moreover, antibodies against MUC1 seem to be a useful tool for the diagnosis of both ExMPD and MPD.
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| Authors | Yoshiyuki Kondo, Kenji Kashima, Tsutomu Daa, Sakuhei Fujiwara, Iwao Nakayama, Shigeo Yokoyama |
| Journal | The American journal of surgical pathology (Am J Surg Pathol) Vol. 26 Issue 5 Pg. 617-23 (May 2002) ISSN: 0147-5185 [Print] United States |
| PMID | 11979091 (Publication Type: Journal Article) |
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