Tricycloclavulone and clavubicyclone, novel prostanoid-related marine oxylipins, isolated from the Okinawan soft coral Clavularia viridis.

Abstract	Two novel prostanoid-related marine oxylipins, tricycloclavulone (1) and clavubicyclone (2), were isolated from the Okinawan soft coral Clavularia viridis. The structures of 1, having a tricyclo[5.3.0.0(1,4)]decane ring system, and 2, having a bicyclo[3.2.1]octane ring system, were elucidated on the basis of spectroscopic analysis. Clavubicyclone showed a moderate growth inhibition activity against tumor cells in vitro.
Authors	Makoto Iwashima, Ikuo Terada, Katsumi Okamoto, Kazuo Iguchi
Journal	The Journal of organic chemistry (J Org Chem) Vol. 67 Issue 9 Pg. 2977-81 (May 03 2002) ISSN: 0022-3263 [Print] United States
PMID	11975555 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Prostaglandins clavubicyclone tricycloclavulone
Topics	Animals Breast Neoplasms Chromatography, High Pressure Liquid Cnidaria (chemistry) Drug Screening Assays, Antitumor Female Humans Japan Magnetic Resonance Spectroscopy Models, Molecular Molecular Conformation Molecular Structure Ovarian Neoplasms Prostaglandins (chemistry, isolation & purification, pharmacology) Spectroscopy, Fourier Transform Infrared Stereoisomerism Tumor Cells, Cultured (drug effects)

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