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Synthesis and immunofluorescence assay of a new biotinylated paclitaxel.

Abstract
7-(5'-Biotinylamidopropanoyl)paclitaxel was synthesised by chemical methods; its immunofluorescence assay and the cell uptake experiments were performed by use of human leukemia U937 cells. The results indicate that paclitaxel is arresting cell cycle at the G(2)M phase only.
AuthorsThota Sambaiah, Ke Yung King, Shwu Chen Tsay, Nai Wen Mei, Sharcon Hakimclahi, Yiu Kay Lai, Chien Hui Lieu, Jih Ru Hwu
JournalEuropean journal of medicinal chemistry (Eur J Med Chem) Vol. 37 Issue 4 Pg. 349-53 (Apr 2002) ISSN: 0223-5234 [Print] France
PMID11960670 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • 7-(5'-Biotinylamidopropanoyl)paclitaxel
  • Antineoplastic Agents
  • Fluorescent Dyes
  • Taxoids
  • Paclitaxel
Topics
  • Antineoplastic Agents (chemical synthesis, metabolism)
  • Fluorescent Antibody Technique
  • Fluorescent Dyes (chemistry)
  • Humans
  • Microtubules (metabolism)
  • Paclitaxel (analogs & derivatives, chemical synthesis, metabolism)
  • Taxoids
  • Tumor Cells, Cultured
  • U937 Cells

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