5-HT(1A) receptor antagonist p-MPPI attenuates acute ethanol effects in mice and rats.

Abstract

The effect of a selective 5-HT(1A) antagonist, 4-(2'-methoxy-)phenyl-1-[2'-(N-2"-pyridinyl)-p-iodobenzamino-]ethyl-piperazine (p-MPPI), on acute ethanol-induced hypothermia, sleep and suppression of acoustic startle reflex in C3H/He mice and Wistar rats was studied. Administration of p-MPPI at the doses of 0.4, 0.7 and 1.0 mg/kg reduced in a dose-dependent manner the ethanol-induced hypothermia and the sleep time and attenuated the ethanol-induced decrease of acoustic startle reflex magnitude in mice. Similar p-MPPI (0.4 mg/kg) effects on ethanol-induced sleep and hypothermia were obtained in rats. It was concluded that 5-HT(1A) receptors were involved in the mechanisms of the ethanol-induced hypothermia and sleep, and that 5-HT(1A) antagonist increased acute ethanol tolerance.

• Authors: Nina K Popova, Elena A Ivanova
• Journal: Neuroscience letters (Neurosci Lett) Vol. 322 Issue 1 Pg. 1-4 (Mar 29 2002) ISSN: 0304-3940 [Print] Ireland
• PMID: 11958829 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Aminopyridines
• Piperazines
• Receptors, Serotonin
• Receptors, Serotonin, 5-HT1
• Serotonin Antagonists
• 4-(2'-methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-iodobenzamido)ethyl)piperazine
• Serotonin
• Ethanol

Topics

• Acute Disease
• Alcohol-Induced Disorders, Nervous System (drug therapy, metabolism, physiopathology)
• Aminopyridines (pharmacology)
• Animals
• Brain (drug effects, metabolism, physiopathology)
• Dose-Response Relationship, Drug
• Drug Interactions (physiology)
• Drug Tolerance (physiology)
• Ethanol (pharmacology)
• Hypothermia (chemically induced, drug therapy, physiopathology)
• Male
• Mice
• Mice, Inbred C3H
• Neurons (drug effects, metabolism)
• Piperazines (pharmacology)
• Rats
• Rats, Wistar
• Receptors, Serotonin (drug effects, metabolism)
• Receptors, Serotonin, 5-HT1
• Reflex, Startle (drug effects, physiology)
• Serotonin (metabolism)
• Serotonin Antagonists (pharmacology)
• Sleep (drug effects, physiology)