Abstract |
A protracted observation over the glucocorticoid function of the adrenal gland in patients with myocardial infarction educed a biphasic nature of changes in the concentration of the plasma and urine corticosteroids in this affection. Most informative are shown to be the evidences of activation of the hypothalamo-hypophysial-adrenal system furnished by the biologically active 11-oxycorticosteroids in the peripheral blood plasma. Psychopharmacological drugs produced a less intensive activation of the glucocorticoid function of the adrenal cortex in the acute period of myocardial infarction and they smooth down a renewed rise in the level of steroid during the subacute period of the disease. Chlorpromazine displays a stronger antistress action than does trioxazine, but the available data justify recommending both these drugs for the treatment of patients with myocardial infarction.
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Authors | I M Miloslavskiĭ, V N Oslopov |
Journal | Kardiologiia
(Kardiologiia)
Vol. 15
Issue 8
Pg. 77-83
(Aug 1975)
ISSN: 0022-9040 [Print] Russia (Federation) |
Vernacular Title | Izmeneniia gliukokortikoidnoĭ funktsii kory nadpochechnikov u bol'nykh infarktom miokarda, lechennykh trioksazinom i aminazinom |
PMID | 1195556
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- 11-Hydroxycorticosteroids
- Morpholines
- Tranquilizing Agents
- Chlorpromazine
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Topics |
- 11-Hydroxycorticosteroids
(blood, urine)
- Adaptation, Physiological
- Adrenal Cortex
(physiopathology)
- Adrenal Glands
(physiopathology)
- Chlorpromazine
(therapeutic use)
- Drug Therapy, Combination
- Humans
- Morpholines
(therapeutic use)
- Myocardial Infarction
(drug therapy, metabolism, physiopathology)
- Tranquilizing Agents
(therapeutic use)
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