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[Changes in the glucocorticoid function of the adrenal cortex in patients with myocardial infarct treated with trioxazine and aminazine].

Abstract
A protracted observation over the glucocorticoid function of the adrenal gland in patients with myocardial infarction educed a biphasic nature of changes in the concentration of the plasma and urine corticosteroids in this affection. Most informative are shown to be the evidences of activation of the hypothalamo-hypophysial-adrenal system furnished by the biologically active 11-oxycorticosteroids in the peripheral blood plasma. Psychopharmacological drugs produced a less intensive activation of the glucocorticoid function of the adrenal cortex in the acute period of myocardial infarction and they smooth down a renewed rise in the level of steroid during the subacute period of the disease. Chlorpromazine displays a stronger antistress action than does trioxazine, but the available data justify recommending both these drugs for the treatment of patients with myocardial infarction.
AuthorsI M Miloslavskiĭ, V N Oslopov
JournalKardiologiia (Kardiologiia) Vol. 15 Issue 8 Pg. 77-83 (Aug 1975) ISSN: 0022-9040 [Print] Russia (Federation)
Vernacular TitleIzmeneniia gliukokortikoidnoĭ funktsii kory nadpochechnikov u bol'nykh infarktom miokarda, lechennykh trioksazinom i aminazinom
PMID1195556 (Publication Type: English Abstract, Journal Article)
Chemical References
  • 11-Hydroxycorticosteroids
  • Morpholines
  • Tranquilizing Agents
  • Chlorpromazine
Topics
  • 11-Hydroxycorticosteroids (blood, urine)
  • Adaptation, Physiological
  • Adrenal Cortex (physiopathology)
  • Adrenal Glands (physiopathology)
  • Chlorpromazine (therapeutic use)
  • Drug Therapy, Combination
  • Humans
  • Morpholines (therapeutic use)
  • Myocardial Infarction (drug therapy, metabolism, physiopathology)
  • Tranquilizing Agents (therapeutic use)

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