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Osteochondromatosis with high concentration of procollagen II C peptide in joint fluid.

Abstract
Procollagen II C peptide is used as a joint fluid marker of collagen synthesis by chondrocytes in patients with osteoarthritis. Since osteochondromatosis activates ectopic chondrogenesis in the synovial membrane, procollagen II C peptide is expected to be a good marker of the disease. Procollagen II C peptide can be used to evaluate the condition of the disease metabolically by simply aspirating the joint fluid. We have experienced a case of osteochondromatosis (Miligram's stage 2) with a high concentration of procollagen II C peptide. This case suggests that the concentration of procollagen II C peptide is a good marker of chondrogenesis by osteochondromatosis.
AuthorsTatsuo Kobayashi, Kyosuke Fujikawa, Yoshihiro Sasazaki, Yoshihiro Aoki
JournalThe Knee (Knee) Vol. 9 Issue 2 Pg. 165-7 (May 2002) ISSN: 0968-0160 [Print] Netherlands
PMID11950585 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Peptide Fragments
  • Procollagen
  • procollagen type II carboxy-terminal peptide
Topics
  • Adult
  • Chondromatosis, Synovial (diagnosis, metabolism)
  • Humans
  • Male
  • Peptide Fragments (analysis)
  • Procollagen (analysis)
  • Synovial Fluid (metabolism)

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