5-HT2A receptor gene polymorphism and eating disorders.

Abstract

Recent studies have reported a genetic association between the -1438 G/A polymorphism within the promoter region of the 5-HT(2A) receptor gene and eating disorders (ED), with conflicting results. To clarify the role of the -1438 G/A polymorphism in different ED categories we have analyzed the genotype and allele frequency distribution in 54 Italian patients with Binge ED (BED) compared to 132 obese non-BED subjects. No significant differences were found between obese BED and obese non-BED individuals, suggesting that this polymorphism does not genetically distinguish these two phenotypes. Moreover, the evaluation of 148 patients with anorexia nervosa and 86 patients with bulimia nervosa revealed an association of the A allele with both these disorders.

• Authors: Valdo Ricca, Benedetta Nacmias, Elena Cellini, Milena Di Bernardo, Carlo Maria Rotella, Sandro Sorbi
• Journal: Neuroscience letters (Neurosci Lett) Vol. 323 Issue 2 Pg. 105-8 (Apr 26 2002) ISSN: 0304-3940 [Print] Ireland
• PMID: 11950504 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptor, Serotonin, 5-HT2A
• Receptors, Serotonin

Topics

• Adult
• Anorexia Nervosa (etiology, genetics)
• Bulimia (etiology, genetics)
• Feeding and Eating Disorders (etiology, genetics)
• Gene Frequency
• Genotype
• Humans
• Middle Aged
• Obesity (etiology, genetics)
• Polymorphism, Genetic (genetics)
• Promoter Regions, Genetic
• Receptor, Serotonin, 5-HT2A
• Receptors, Serotonin (genetics)