Genetic variations in HLA-B region and hypersensitivity reactions to abacavir.

Abstract

Hypersensitivity to abacavir affects about 4% of patients who receive the drug for HIV-1 infection. We did a retrospective, case-control study to identify multiple markers in the vicinity of HLA-B associated with hypersensitivity reactions. HLA-B57 was present in 39 (46%) of 84 patients versus four (4%) of 113 controls (p<0 small middle dot0001). However, because of low numbers of women and other ethnic groups enrolled, these findings relate largely to white men. The lower sensitivity of HLA-B57 for predicting hypersensitivity to abacavir identified in this study compared with a previous report highlights that predictive values for markers will vary across populations. Clinical monitoring and management of hypersensitivity reactions among patients receiving abacavir must remain unchanged.

• Authors: Seth Hetherington, Arlene R Hughes, Michael Mosteller, Denise Shortino, Katherine L Baker, William Spreen, Eric Lai, Kirstie Davies, Abigail Handley, David J Dow, Mary E Fling, Michael Stocum, Clive Bowman, Linda M Thurmond, Allen D Roses
• Journal: Lancet (London, England) (Lancet) Vol. 359 Issue 9312 Pg. 1121-2 (Mar 30 2002) ISSN: 0140-6736 [Print] England
• PMID: 11943262 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-HIV Agents
• Dideoxynucleosides
• Genetic Markers
• HLA-B Antigens
• HLA-B57 antigen
• Reverse Transcriptase Inhibitors
• Tumor Necrosis Factor-alpha
• abacavir

Topics

• Adult
• Aged
• Anti-HIV Agents (adverse effects)
• Case-Control Studies
• Dideoxynucleosides (adverse effects)
• Drug Hypersensitivity (diagnosis, etiology, genetics)
• Female
• Genetic Markers
• Genetic Variation
• HIV Infections (drug therapy)
• HIV-1
• HLA-B Antigens (genetics)
• Humans
• Male
• Middle Aged
• Polymorphism, Genetic
• Predictive Value of Tests
• Racial Groups (genetics)
• Retrospective Studies
• Reverse Transcriptase Inhibitors (adverse effects)
• Sensitivity and Specificity
• Tumor Necrosis Factor-alpha (genetics)