HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Findings of the Naftidrofuryl in Quality of Life (NIQOL) European study program.

AbstractBACKGROUND:
We report in this paper the findings of a pooled analysis of 3 previously published studies undertaken in Germany, France and Belgium to assess the effects of naftidrofuryl on the quality of life of patients with intermittent claudication.
METHODS:
A total of 754 patients were randomised in the 3 studies, 709 of whom (358 naftidrofuryl, 351 placebo) were available for the primary intention-to-treat analysis. The primary outcome variable was the change in the disease-related limitation of the quality of life as measured by the CLAU-S questionnaire. This instrument which has been validated in an international study, comprises 47 questions covering 5 dimensions: "daily living", "pain", "social life", "disease specific anxiety" and "mood".
RESULTS:
A multivariate analysis of covariance adjusted for baseline values, study effect and first order study treatment interaction, demonstrated the global superiority of naftidrofuryl over placebo (p<0.001). A separate covariance analysis for the 5 dimensions showed highly significant differences for "daily living", "pain", "social life" and "mood" (all p<0.01).
CONCLUSIONS:
In conclusion, this pooled analysis has shown that naftidrofuryl can significantly improve the quality of life of patients with intermittent claudication. These findings, taken together with evidence from previous studies that it improves treadmill walking distances, suggest that naftidrofuryl can play a useful role in the treatment of this condition.
AuthorsF Spengel, D Clément, H Boccalon, F Liard, T Brown, P Lehert
JournalInternational angiology : a journal of the International Union of Angiology (Int Angiol) Vol. 21 Issue 1 Pg. 20-7 (Mar 2002) ISSN: 0392-9590 [Print] Italy
PMID11941270 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Serotonin Antagonists
  • Nafronyl
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Europe (epidemiology)
  • Female
  • Follow-Up Studies
  • Humans
  • Intermittent Claudication (complications, drug therapy)
  • Male
  • Middle Aged
  • Nafronyl (adverse effects, therapeutic use)
  • Pain (drug therapy, etiology)
  • Patient Compliance
  • Prospective Studies
  • Quality of Life
  • Serotonin Antagonists (adverse effects, therapeutic use)
  • Severity of Illness Index
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: