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Results of clinical examinations, laboratory tests, and ultrasonography in dogs with pituitary-dependent hyperadrenocorticism treated with trilostane.

AbstractOBJECTIVE:
To determine the efficacy of trilostane, a 3beta-hydroxysteroid dehydrogenase inhibitor, in dogs with pituitary-dependent hyperadrenocorticism (PDH).
ANIMALS:
11 dogs with PDH.
PROCEDURE:
The initial dose of trilostane was 30 mg, PO, q 24 h for dogs that weighed < 5 kg and 60 mg, PO, q 24 h for dogs that weighed > or = 5 kg. A CBC count, serum biochemical analyses, urinalysis, ACTH stimulation test, and ultrasonographic evaluation of the adrenal glands were performed in each dog 1, 3 to 4, 6 to 7, 12 to 16, and 24 to 28 weeks after initiation of treatment.
RESULTS:
All dogs responded well to treatment. All had reductions in polyuria-polydipsia and panting and an increase in activity. Polyphagia decreased in 9 of 10 dogs, and 9 of 11 dogs had improvement of coat quality and skin condition. Concentration of cortisol after ACTH stimulation significantly decreased by 1 week after initiation of treatment. After treatment for 6 months, clinical signs resolved in 9 dogs. In the other 2 dogs, marked clinical improvement was reported for 1 dog, and moderate improvement was reported in the other dog. Ultrasonographically, there was a considerable change in the parenchyma and an increase in size of the adrenal glands. Adverse effects consisted of 1 dog with transient lethargy and 1 dog with anorexia.
CONCLUSIONS AND CLINICAL RELEVANCE:
Trilostane is an efficacious and safe medication for treatment of dogs with PDH. Additional studies in a larger group of dogs and characterization of progressive changes in adrenal glands are needed.
AuthorsNadja S Ruckstuhl, Claudia S Nett, Claudia E Reusch
JournalAmerican journal of veterinary research (Am J Vet Res) Vol. 63 Issue 4 Pg. 506-12 (Apr 2002) ISSN: 0002-9645 [Print] United States
PMID11939311 (Publication Type: Journal Article)
Chemical References
  • Enzyme Inhibitors
  • Dihydrotestosterone
  • Adrenocorticotropic Hormone
  • trilostane
  • Hydrocortisone
Topics
  • Adrenocortical Hyperfunction (blood, diagnostic imaging, drug therapy, veterinary)
  • Adrenocorticotropic Hormone (administration & dosage)
  • Animals
  • Blood Cell Count (veterinary)
  • Blood Chemical Analysis (veterinary)
  • Dihydrotestosterone (adverse effects, analogs & derivatives, therapeutic use)
  • Dog Diseases (blood, diagnostic imaging, drug therapy)
  • Dogs
  • Enzyme Inhibitors (adverse effects, therapeutic use)
  • Female
  • Hydrocortisone (blood)
  • Male
  • Pituitary Diseases (blood, diagnostic imaging, drug therapy, veterinary)
  • Polyuria (drug therapy, veterinary)
  • Prospective Studies
  • Ultrasonography

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