[Experimental study on treatment of chronic renal failure with yishen qudu capsule].

Abstract

OBJECTIVE:

To study the mechanism of action of Yishen Qudu capsule (YSQDC) in experimental rat model of chronic renal failure (CRF).

METHODS:

Membranous nephropathy model was induced by cationized bovine serum albumin intravenous administration in rats for 7 weeks and developed to CRF. The model was then treated with YSQDC of large or small dose by gastrogavage for 5 weeks. Oxidated starch was used in the control group.

RESULTS:

YSQDC could reduce proteinuria, serum creatinine, blood urea nitrogen, total cholesterol, triglyceride and serum circulating immune complex (P < 0.01 or P < 0.05), it also reduced the kidney coefficient, glomerular cells and tubular protein cast significantly (all P < 0.01). The strength of immune fluorescence weakened remarkably (P < 0.01). The pathological lesions improved significantly after treatment under light and electron-microscopic examination.

CONCLUSION:

YSQDC could improve renal function significantly and inhibit the progression of CRF.

• Authors: G Wang, C Li, L Jin
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 20 Issue 10 Pg. 761-3 (Oct 2000) ISSN: 1003-5370 [Print] China
• PMID: 11938814 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Capsules
• Drugs, Chinese Herbal

Topics

• Animals
• Capsules
• Drugs, Chinese Herbal (pharmacology)
• Glomerulonephritis, Membranous (complications)
• Kidney (pathology)
• Kidney Failure, Chronic (drug therapy, immunology, pathology)
• Male
• Rats
• Rats, Sprague-Dawley