[Bone evaluation in ten adults with cutaneous mastocytosis].

Abstract

BACKGROUND:

To systematically evaluate the bone status, searching for osteoporosis in patients with cutaneous mastocytosis.

PATIENTS AND METHODS:

In a prospective study from March 1997 to June 2000, we included all new patients examined for cutaneous signs of mastocytosis. Past history, physical examination, skin biopsy, laboratory tests, bone densitometry, cytology and histopathology of bone marrow and other complementary investigations were performed in all these patients.

RESULTS:

Ten patients were included. Two patients had osteoporosis. Five others had osteopenia. Four patients had bone marrow involvement due to mastocytosis. One of these four patients had myelodysplasia.

DISCUSSION:

This study suggests better investigation of bone density and bone marrow in patients who have cutaneous mastocytosis. Systematic histopathology of bone marrow and osteodensitometry help to detect patients with systemic involvement. Bone densitometry is particularly effective for early detection of patients at risk for fracture and is of practical interest since patients with osteoporosis can now be treated with Pamidronate.

• Authors: P Armingaud, D Zerkak, E Lespessailles, C Petavy-Catala, R Kerdraon, C L Benhamou, E Estève
• Journal: Annales de dermatologie et de venereologie (Ann Dermatol Venereol) Vol. 129 Issue 2 Pg. 170-2 (Feb 2002) ISSN: 0151-9638 [Print] France
• Vernacular Title: Evaluation de l'état osseux chez dix adultes atteints de mastocytose cutanée.
• PMID: 11937953 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• Diphosphonates
• Pamidronate

Topics

• Adult
• Anti-Inflammatory Agents (therapeutic use)
• Bone Density
• Bone Diseases (diagnosis)
• Bone Diseases, Metabolic (diagnosis)
• Bone Marrow Diseases (diagnosis)
• Diphosphonates (therapeutic use)
• Female
• Humans
• Male
• Mastocytosis (complications)
• Middle Aged
• Myelodysplastic Syndromes (diagnosis)
• Osteoporosis (diagnosis, drug therapy)
• Pamidronate
• Prospective Studies