Abstract | BACKGROUND:
Thrombophilia is increasingly recognized as a risk factor for deep venous thrombosis (DVT), which in turn is a major risk factor for chronic venous ulceration (CVU). However, the relationship between thrombophilia and CVU remains unknown. The aim of this study was to define the prevalence of thrombophilia in patients with CVU and to determine whether this is associated with a history or duplex scan evidence of DVT. METHODS: RESULTS: CONCLUSION: Patients with CVU have a 41% prevalence rate of thrombophilia. This rate is two to 30 times higher than the rate of the general population but is similar to that reported for patients with previous DVT. However, in patients with CVU, thrombophilia does not appear to be related to a history of DVT, a pattern of reflux, or severity of disease. Many patients with CVU may have unsuspected postthrombotic disease.
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Authors | Rhoda K Mackenzie, Christopher A Ludlam, C Vaughan Ruckley, Paul L Allan, Paul Burns, Andrew W Bradbury |
Journal | Journal of vascular surgery
(J Vasc Surg)
Vol. 35
Issue 4
Pg. 718-22
(Apr 2002)
ISSN: 0741-5214 [Print] United States |
PMID | 11932669
(Publication Type: Journal Article)
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Topics |
- Aged
- Blood Coagulation Tests
- Case-Control Studies
- Female
- Humans
- Male
- Middle Aged
- Prevalence
- Prospective Studies
- Risk Factors
- Thrombophilia
(epidemiology)
- Ultrasonography, Doppler, Duplex
- Varicose Ulcer
(blood, diagnostic imaging)
- Venous Thrombosis
(blood, epidemiology)
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