Abstract | AIM: METHODS AND RESULTS: Two families are described each of which has one member with classical antimitochondrial antibody positive biopsy-proven primary biliary cirrhosis and a first degree relative with antimitochondrial antibody negative but antinuclear antibody positive autoimmune cholangitis (biopsy proven in one case). Study of such families should allow analysis of the contribution of shared genetic risk factors versus varying environmental triggering mechanisms to disease pathogenesis. CONCLUSIONS: We suggest a European registry of families, such as the two described, which are rare within one centre, to facilitate elucidation of pathogenetic factors.
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Authors | K Agarwal, D E J Jones, F E Watt, A D Burt, A Floreani, M F Bassendine |
Journal | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
(Dig Liver Dis)
Vol. 34
Issue 1
Pg. 50-2
(Jan 2002)
ISSN: 1590-8658 [Print] Netherlands |
PMID | 11930900
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antibodies, Antinuclear
- Autoantibodies
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Topics |
- Adult
- Antibodies, Antinuclear
(blood)
- Autoantibodies
(blood)
- Autoimmune Diseases
(genetics, immunology)
- Cholangitis
(genetics, immunology)
- Female
- Humans
- Liver
(pathology)
- Liver Cirrhosis, Biliary
(genetics, immunology)
- Middle Aged
- Mitochondria
(immunology)
- Risk
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