The interleukin-10 family of cytokines.

Abstract

A family of interleukin-10 (IL-10)-related cytokines has emerged, comprising a series of herpesviral and poxviral members and several cellular sequence paralogs, including IL-19, IL-20, IL-22 [IL-10-related T-cell-derived inducible factor (IL-TIF)], IL-24 [melanoma differentiation-associated antigen 7 (MDA-7)] and IL-26 (AK155). Although the predicted helical structure of these homodimeric molecules is conserved, certain receptor-binding residues are variable and define the interaction with specific heterodimers of different type-2 cytokine receptors. This leads, through the activation of signal transducer and activator of transcription (STAT) factors, to diverse biological effects. For example, whereas IL-10 is a well-studied pleiotropic immunosuppressive and immunostimulatory cytokine, IL-22/IL-TIF mediates acute-phase response signals in hepatocytes and IL-20 induces the hyperproliferation of keratinocytes, which has been proposed as a pathogenic mechanism of psoriasis.

• Authors: Helmut Fickenscher, Simon Hör, Heide Küpers, Andrea Knappe, Sabine Wittmann, Heinrich Sticht
• Journal: Trends in immunology (Trends Immunol) Vol. 23 Issue 2 Pg. 89-96 (Feb 2002) ISSN: 1471-4906 [Print] England
• PMID: 11929132 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• IL26 protein, human
• Interleukins
• Receptors, Interleukin
• Receptors, Interleukin-10
• Interleukin-10

Topics

• Amino Acid Sequence
• Animals
• Humans
• Interleukin-10 (chemistry, genetics, immunology, therapeutic use)
• Interleukins
• Molecular Sequence Data
• Receptors, Interleukin (immunology)
• Receptors, Interleukin-10