Reduction in the incidence of alveolar osteitis in patients treated with the SaliCept patch, containing Acemannan hydrogel.

Abstract

PURPOSE:

In the present study, we compared the incidence of alveolar osteitis (AO) in patients treated with either clindamycin-soaked Gelfoam (Pharmacia and Upjohn Co, Kalamazoo, MI) or SaliCept Patches (Carrington Laboratories, Inc, Irving, TX). The SaliCept Patch is a freeze-dried pledget that contains Acemannan Hydrogel (Carrington Laboratories) obtained from the clear inner gel of Aloe vera L.

PATIENTS AND METHODS:

A retrospective evaluation was performed of the records of 587 patients (1,031 sockets) whose extraction sites had been treated with clindamycin-soaked Gelfoam. A prospective trial was conducted in which 607 patients (1,064 sockets) had 2 SaliCept Patches placed immediately after extraction. The same surgeon treated all patients.

RESULTS:

Analysis restricted to mandibular third molar sites showed that 78 of 975 sites (8.0%) in the Gelfoam group developed AO, whereas only 11 of 958 sites (1.1%) in the SaliCept group developed AO (P <.0001). Further analysis of all extraction sites revealed that the incidence of AO in the Gelfoam group was 7.6% compared with 1.1% in the SaliCept-treated group (P <.0001).

CONCLUSIONS:

The study results suggest that the SaliCept Patch significantly reduces the incidence of AO compared with clindamycin-soaked Gelfoam.

• Authors: Miles R Poor, John E Hall, Anne S Poor
• Journal: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons (J Oral Maxillofac Surg) Vol. 60 Issue 4 Pg. 374-9; discussion 379 (Apr 2002) ISSN: 0278-2391 [Print] United States
• PMID: 11928091 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2002 American Association of Oral and Maxillofacial Surgeons

Chemical References

• Anti-Bacterial Agents
• Hemostatics
• Mannans
• Plant Extracts
• Clindamycin
• acemannan

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Aloe
• Anti-Bacterial Agents (therapeutic use)
• Child
• Clindamycin (therapeutic use)
• Dry Socket (etiology, prevention & control)
• Female
• Gelatin Sponge, Absorbable (therapeutic use)
• Hemostatics (therapeutic use)
• Humans
• Male
• Mannans (therapeutic use)
• Middle Aged
• Phytotherapy
• Plant Extracts (therapeutic use)
• Retrospective Studies
• Tooth Extraction (adverse effects)
• Treatment Outcome