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Replication of an avian myxovirus in tumor cell cultures obtained from effusions of mammary carcinoma patients.

Abstract
In view of the possible use of viruses for the immunotherapy of breast cancer, the replication of a strain of fowl plaque virus was studied in the tumor cells of 11 mammary carcinoma patients with malignant effusions. The tumor cells were obtained by centrifugation on iodamide solutions, then cultured in vitro, and infected by a fowl plaque virus previously adapted to grow in a mammary carcinoma cell line. Virus multiplication was observed in all cases, a prerequisite for the use of autologous viral oncolysates for immunotherapy in mammary carcinoma patients.
AuthorsH J Illiger, C Sauter, J Lindenmann
JournalCancer research (Cancer Res) Vol. 35 Issue 12 Pg. 3623-7 (Dec 1975) ISSN: 0008-5472 [Print] United States
PMID1192423 (Publication Type: Journal Article)
Chemical References
  • Iodamide
Topics
  • Ascitic Fluid
  • Breast Neoplasms
  • Cell Separation (methods)
  • Cells, Cultured
  • Humans
  • Influenza A virus (growth & development)
  • Iodamide
  • Pleural Effusion
  • Virus Replication

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