| Abstract | The multicomponent VP-4 vaccine from Klebsiella pneumonia, Staphyloccocus aureus, Proteus vulgaris, Escherichia coli antigens was used to prevent acute respiratory diseases (ARD) at preschoolchildren's establishments. Prevention was effected during an influenza epidemic with a drastic rise in the incidence of ARD. The VP-4 use involved 3 nasal and 6-9 oral administrations of the drug at an interval of 3-4 days. The duration of the course was 26 +/- 4 days. The preventive action of VP-4 on the incidence of ARD was followed up for 14 months after vaccination. One group comprised 89 vaccinated children, a matched group included 69 children whose age was 2 to 6 years. Immunoprophylaxis was found to promote a reduction in the number of children who had 4 ARD episodes or more during the whole follow-up. Administration of VP-4 prevented the development of repeated episodes ARD in a group of children aged 2-3 years and in frequently ill children who had 3 infections or more in the previous year. The slight reactogenicity of the drug and its long-term preventive effect allow this method of immunoprophylaxis to be recommended for frequently ill children, for those at high risk, and for those in the junior age group (under 4 years) before going to preschoolchildren's establishments. |
| Authors | N B Egorova, B F Semenov, E A Kurbatova, V N Efremova, I M Gruber, L A Kuz'mina, I B Semenova |
| Journal | Vestnik Rossiĭskoĭ akademii meditsinskikh nauk / Rossiĭskaia akademiia meditsinskikh nauk
(Vestn Ross Akad Med Nauk)
Issue 2
Pg. 29-30
( 2002)
ISSN: 0869-6047 Russia |
| Vernacular Title | Isopol'zovanie polikomponentnoĭ vaktsiny VP-4 dlia profilaktiki ostrykh respiratornykh zabolevaniĭ v detskikh doshkol'nykh uchrezhdeniiakh. |
| PMID | 11924123
(Publication Type: English Abstract, Journal Article)
|
| Chemical References |
- Bacterial Vaccines
- VP-4 vaccine
- Vaccines, Combined
|
| Topics |
- Bacterial Vaccines
(chemistry, therapeutic use)
- Child
- Child, Preschool
- Humans
- Incidence
- Respiratory Tract Infections
(epidemiology, prevention & control)
- School Health Services
(organization & administration)
- Time Factors
- Vaccines, Combined
|
