Abstract | RATIONALE: OBJECTIVES: Determine whether the accumulation of low loaded Gd- albumin improves visualization of malignant tumors by MRI. METHODS: Twelve nude mice with heterotransplanted squamous cell carcinomas were studied. The signal intensity of tumor, blood, liver, kidney and muscle tissue was studied in MR images after application of Gd- albumin during a period of 144 hours. MRI results were histologically correlated after simultaneously injection of Gd- and fluorescein-labeled albumins in 9 nude mice. RESULTS: Although liver and kidney had a maximum increase in signal intensity within 30 minutes, tumors showed a delayed 51% increase in the 24 hours after application. Histologic and fluorescence evaluation demonstrated albumin localization in tumors predominantly in stroma and necroses. CONCLUSIONS: Gd- albumin is efficiently accumulated in SCC transplants. MRI with low loaded Gd- albumin may offer relevant opportunities for recognizing tumors sensitive to a therapy with cyostic drug-labeled albumins.
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Authors | F Kiessling, C Fink, M Hansen, M Bock, H Sinn, H H Schrenk, M Krix, T Egelhof, N E Fusenig, S Delorme |
Journal | Investigative radiology
(Invest Radiol)
Vol. 37
Issue 4
Pg. 193-8
(Apr 2002)
ISSN: 0020-9996 [Print] United States |
PMID | 11923641
(Publication Type: Journal Article)
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Chemical References |
- Albumins
- Contrast Media
- albumin-(gadolinium-DTPA)
- Gadolinium DTPA
- Fluorescein
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Topics |
- Albumins
(pharmacokinetics)
- Animals
- Carcinoma, Squamous Cell
(metabolism, pathology)
- Contrast Media
- Fluorescein
(pharmacokinetics)
- Gadolinium DTPA
(pharmacokinetics)
- Kidney
(metabolism)
- Liver
(metabolism)
- Magnetic Resonance Imaging
(methods)
- Mice
- Mice, Nude
- Muscles
(metabolism)
- Neoplasm Transplantation
- Transplantation, Heterologous
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