Abstract |
Mouse mammary tumor virus (MMTV) is acquired by neonates through milk and first infects lymphocytes in Peyer's patches. We show here that newborn mice lacking beta7 integrin or L-selectin were infected with MMTV at wild-type levels in both their lymphoid and mammary tissues. Superantigen-mediated activation and cognate T cell deletion were also unimpaired in both types of null mice. A large proportion of neonatal Peyer's patch lymphocytes in wild-type mice were beta7 and beta1 integrin low and both populations increased in response to MMTV infection. These results suggest that adhesion molecules other than beta7 integrin or L-selectin play a role in lymphocyte homing in the gut, peripheral lymph nodes and mammary gland in response to MMTV infection.
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Authors | Jennifer Czarneski, Paula Berguer, Pedro Bekinschtein, David C Kim, Paul Hakimpour, Norbert Wagner, Irene Nepomnaschy, Isabel Piazzon, Susan R Ross |
Journal | European journal of immunology
(Eur J Immunol)
Vol. 32
Issue 4
Pg. 945-56
(04 2002)
ISSN: 0014-2980 [Print] Germany |
PMID | 11920560
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antigens, Viral
- Cadherins
- Cell Adhesion Molecules
- Cytokines
- Immunoglobulins
- Integrin beta Chains
- Integrins
- Madcam1 protein, mouse
- Mucins
- Mucoproteins
- Superantigens
- integrin alpha4beta7
- integrin alphaEbeta7
- integrin beta7
- L-Selectin
- sulfated glycoprotein p50
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Topics |
- Animals
- Animals, Newborn
- Antigens, Viral
(immunology)
- B-Lymphocytes
(immunology, virology)
- Cadherins
(physiology)
- Cell Adhesion
- Cell Adhesion Molecules
- Cell Movement
- Cytokines
(physiology)
- Female
- Immunoglobulins
(physiology)
- Integrin beta Chains
- Integrins
(deficiency, genetics, physiology)
- Intestinal Mucosa
(immunology, pathology, virology)
- L-Selectin
(genetics, physiology)
- Lactation
- Lymphocyte Cooperation
- Lymphocyte Subsets
(cytology, immunology, virology)
- Lymphoid Tissue
(immunology, pathology)
- Mammary Glands, Animal
(immunology, pathology)
- Mammary Tumor Virus, Mouse
(physiology)
- Mice
- Mice, Inbred C3H
- Mice, Knockout
- Milk
(virology)
- Mucins
(physiology)
- Mucoproteins
(physiology)
- Peyer's Patches
(immunology, virology)
- Retroviridae Infections
(immunology)
- Superantigens
(immunology)
- T-Lymphocyte Subsets
(immunology, virology)
- Tumor Virus Infections
(immunology)
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