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Neonatal infection with a milk-borne virus is independent of beta7 integrin- and L-selectin-expressing lymphocytes.

Abstract
Mouse mammary tumor virus (MMTV) is acquired by neonates through milk and first infects lymphocytes in Peyer's patches. We show here that newborn mice lacking beta7 integrin or L-selectin were infected with MMTV at wild-type levels in both their lymphoid and mammary tissues. Superantigen-mediated activation and cognate T cell deletion were also unimpaired in both types of null mice. A large proportion of neonatal Peyer's patch lymphocytes in wild-type mice were beta7 and beta1 integrin low and both populations increased in response to MMTV infection. These results suggest that adhesion molecules other than beta7 integrin or L-selectin play a role in lymphocyte homing in the gut, peripheral lymph nodes and mammary gland in response to MMTV infection.
AuthorsJennifer Czarneski, Paula Berguer, Pedro Bekinschtein, David C Kim, Paul Hakimpour, Norbert Wagner, Irene Nepomnaschy, Isabel Piazzon, Susan R Ross
JournalEuropean journal of immunology (Eur J Immunol) Vol. 32 Issue 4 Pg. 945-56 (04 2002) ISSN: 0014-2980 [Print] Germany
PMID11920560 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antigens, Viral
  • Cadherins
  • Cell Adhesion Molecules
  • Cytokines
  • Immunoglobulins
  • Integrin beta Chains
  • Integrins
  • Madcam1 protein, mouse
  • Mucins
  • Mucoproteins
  • Superantigens
  • integrin alpha4beta7
  • integrin alphaEbeta7
  • integrin beta7
  • L-Selectin
  • sulfated glycoprotein p50
Topics
  • Animals
  • Animals, Newborn
  • Antigens, Viral (immunology)
  • B-Lymphocytes (immunology, virology)
  • Cadherins (physiology)
  • Cell Adhesion
  • Cell Adhesion Molecules
  • Cell Movement
  • Cytokines (physiology)
  • Female
  • Immunoglobulins (physiology)
  • Integrin beta Chains
  • Integrins (deficiency, genetics, physiology)
  • Intestinal Mucosa (immunology, pathology, virology)
  • L-Selectin (genetics, physiology)
  • Lactation
  • Lymphocyte Cooperation
  • Lymphocyte Subsets (cytology, immunology, virology)
  • Lymphoid Tissue (immunology, pathology)
  • Mammary Glands, Animal (immunology, pathology)
  • Mammary Tumor Virus, Mouse (physiology)
  • Mice
  • Mice, Inbred C3H
  • Mice, Knockout
  • Milk (virology)
  • Mucins (physiology)
  • Mucoproteins (physiology)
  • Peyer's Patches (immunology, virology)
  • Retroviridae Infections (immunology)
  • Superantigens (immunology)
  • T-Lymphocyte Subsets (immunology, virology)
  • Tumor Virus Infections (immunology)

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