Abstract | BACKGROUND: METHODS: RESULTS: Among the markers tested, ICTP showed the highest sensitivity (58.0%) in esophageal SCC sera. Positive ICTP levels were significantly correlated with tumor progression variables, such as tumor depth > or = T2, regional lymph node metastasis (N1), distant metastasis (M1), TNM stage > or = II, and maximal tumor length greater than 50 mm. Survival analyses of 29 patients who underwent curative resection demonstrated that patients who were positive for ICTP had significantly worse outcomes in terms of overall, disease specific, and disease free survival than those who were negative. Multivariate analyses confirmed that serum ICTP levels provided an independent prognostic indicator of overall and disease specific survival. However, serum ICTP values did not correlate with prognosis or treatment response in 17 unresectable cases treated by chemoradiotherapy. CONCLUSIONS: Our results indicated that serum ICTP concentrations might be a novel prognostic tumor marker for assessing the progression of esophageal SCC.
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Authors | Yoshihiro Nabeya, Hideaki Shimada, Shinichi Okazumi, Hisahiro Matsubara, Yoshio Gunji, Takao Suzuki, Takenori Ochiai |
Journal | Cancer
(Cancer)
Vol. 94
Issue 4
Pg. 940-9
(Feb 15 2002)
ISSN: 0008-543X [Print] United States |
PMID | 11920462
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2002 American Cancer Society. DOI 10.1002/cncr.10267 |
Chemical References |
- Biomarkers, Tumor
- Collagen Type I
- Cross-Linking Reagents
- Peptide Fragments
- Procollagen
- procollagen type I carboxy terminal peptide
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(analysis)
- Carcinoma, Squamous Cell
(genetics, pathology)
- Collagen Type I
(blood, metabolism)
- Cross-Linking Reagents
- Disease Progression
- Esophageal Neoplasms
(genetics, pathology)
- Female
- Humans
- Male
- Middle Aged
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Peptide Fragments
(blood)
- Procollagen
(blood)
- Prognosis
- Prospective Studies
- Radioimmunoassay
- Sensitivity and Specificity
- Survival Analysis
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