Abstract | AIM: METHODS: A total of 20 patients clinically suspected for OM (n = 12), SD (n = 3) and FUO (n = 5) were included in our retrospective analysis. The additional criterion was a positive 3-phase bone scan for OM, or a 2-phase bone scan in case of SD. Planar whole body scans and static acquisitions were performed 1 and 4 h after application of 370 MBq Tc-99m ciprofloxacin. In 10 patients with suspected OM, additional immunoscintigraphy using Tc-99m labelled monoclonal antibodies (Mab BW 250/183) was performed and the correlation of infection to bloodpool and antigranulocyte scintigraphy was analysed. RESULTS: OM: Bacterial infection was confirmed in 8 of 15 lesions. Infection demonstrated true positive (TP) results in 7 of 8, true negative (TN) results in 2 of 7, false positive (FP) results in 5 of 7 patients and one false negative (FN) result. A strong correlation could be demonstrated between T/NT ratios of infection and bloodpool Tc-99m medronate imaging (r = 0.84, 0.88) and between infection and BW 250/183 (r = 0.92, 0.90). Using a threshold of 2.0 for T/NT ratio, only TP results could be observed whereas a T/NT in the range of 1.0-2.0 could not discriminate between septic and aseptic inflammation. Concordant results with Mab BW 250/183 could only be observed in 5 of 10 patients (4 TP, 1 TN) by showing 4 FP and 1 FN lesions with IF. CONCLUSION: Non-specific uptake of infection can be observed in a variety of clinical situations with moderate uptake, by showing a strong correlation with blood-pool imaging. Nevertheless, intense uptake may be specific for septic inflammation.
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Authors | H J Gallowitsch, M Heinisch, P Mikosch, E Kresnik, G Kumnig, I Gomez, P Lind |
Journal | Nuklearmedizin. Nuclear medicine
(Nuklearmedizin)
Vol. 41
Issue 1
Pg. 30-6
(Feb 2002)
ISSN: 0029-5566 [Print] Germany |
Vernacular Title | Tc-99m-Ciprofloxacin bei Verdacht auf periphere Osteomyelitis, Spondylodiszitis und Fieber unklarer Genese in einem klinisch selektierten Patientengut--vorläufige Ergebnisse. |
PMID | 11917346
(Publication Type: Journal Article)
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Chemical References |
- Organotechnetium Compounds
- Radiopharmaceuticals
- Technetium Tc 99m ciprofloxacin
- Ciprofloxacin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Bacterial Infections
(diagnostic imaging)
- Bone and Bones
(diagnostic imaging)
- Ciprofloxacin
(analogs & derivatives)
- Diagnosis, Differential
- Discitis
(diagnostic imaging)
- Female
- Fever of Unknown Origin
(diagnostic imaging)
- Humans
- Male
- Middle Aged
- Organotechnetium Compounds
- Osteomyelitis
(diagnostic imaging)
- Radioimmunodetection
- Radiopharmaceuticals
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