Indinavir-associated interstitial nephritis and urothelial inflammation: clinical and cytologic findings.

Abstract

The objective of the present study was to characterize the genitourinary syndromes that accompany indinavir-associated pyuria. Of 23 indinavir-treated patients with persistent pyuria, 4 had isolated interstitial nephritis, 10 had both interstitial nephritis and urothelial inflammation, 7 had isolated urothelial inflammation, and 2 had pyuria with nonspecific urinary tract inflammation. A total of 21 patients had multinucleated histiocytes identified by cytologic testing of urine specimens. Urine abnormalities resolved in all 20 patients who stopped receiving indinavir therapy. Pyuria continued in the 3 patients who continued receiving indinavir. Six patients had elevated serum creatinine levels, which returned to baseline levels when indinavir was discontinued. In conclusion, indinavir-associated pyuria was frequently associated with evidence of interstitial nephritis and/or urothelial inflammation, multinucleated histiocytes were commonly present in urine specimens, and cessation of indinavir therapy was associated with prompt resolution of urine abnormalities.

• Authors: Jeffrey B Kopp, Judith Falloon, Armando Filie, Andrea Abati, Christine King, Glen L Hortin, JoAnn M Mican, Ellen Vaughan, Kirk D Miller
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 34 Issue 8 Pg. 1122-8 (Apr 15 2002) ISSN: 1537-6591 [Electronic] United States
• PMID: 11915002 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HIV Protease Inhibitors
• Indinavir

Topics

• Adult
• Female
• HIV Protease Inhibitors (adverse effects)
• Humans
• Indinavir (adverse effects)
• Inflammation (chemically induced)
• Male
• Middle Aged
• Nephritis, Interstitial (chemically induced)
• Pyuria (chemically induced)
• Urothelium (drug effects, pathology)