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Indinavir-associated interstitial nephritis and urothelial inflammation: clinical and cytologic findings.

Abstract
The objective of the present study was to characterize the genitourinary syndromes that accompany indinavir-associated pyuria. Of 23 indinavir-treated patients with persistent pyuria, 4 had isolated interstitial nephritis, 10 had both interstitial nephritis and urothelial inflammation, 7 had isolated urothelial inflammation, and 2 had pyuria with nonspecific urinary tract inflammation. A total of 21 patients had multinucleated histiocytes identified by cytologic testing of urine specimens. Urine abnormalities resolved in all 20 patients who stopped receiving indinavir therapy. Pyuria continued in the 3 patients who continued receiving indinavir. Six patients had elevated serum creatinine levels, which returned to baseline levels when indinavir was discontinued. In conclusion, indinavir-associated pyuria was frequently associated with evidence of interstitial nephritis and/or urothelial inflammation, multinucleated histiocytes were commonly present in urine specimens, and cessation of indinavir therapy was associated with prompt resolution of urine abnormalities.
AuthorsJeffrey B Kopp, Judith Falloon, Armando Filie, Andrea Abati, Christine King, Glen L Hortin, JoAnn M Mican, Ellen Vaughan, Kirk D Miller
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 34 Issue 8 Pg. 1122-8 (Apr 15 2002) ISSN: 1537-6591 [Electronic] United States
PMID11915002 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • HIV Protease Inhibitors
  • Indinavir
Topics
  • Adult
  • Female
  • HIV Protease Inhibitors (adverse effects)
  • Humans
  • Indinavir (adverse effects)
  • Inflammation (chemically induced)
  • Male
  • Middle Aged
  • Nephritis, Interstitial (chemically induced)
  • Pyuria (chemically induced)
  • Urothelium (drug effects, pathology)

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