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Candida endocarditis treated with a combination of antifungal chemotherapy and aortic valve replacement.

Abstract
A case of Candida albicans endocarditis is described in which treatment with 5-fluorocytosine was started after aortic valve replacement, but relapse followed discontinuance of treatment. At a second operation the aortic valve was replaced under 5-fluorocytosine cover and treatment was continued with both 5-fluorocytosine and amphotericin-B. No resistance to 5-fluorocytosine developed, and the candida infection was eradicated. The patient is well 22 months after his operation.
AuthorsD L Stone
JournalBritish heart journal (Br Heart J) Vol. 37 Issue 11 Pg. 1191-4 (Nov 1975) ISSN: 0007-0769 [Print] England
PMID1191435 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Amphotericin B
  • Flucytosine
Topics
  • Amphotericin B (therapeutic use)
  • Aortic Valve (surgery)
  • Candidiasis
  • Endocarditis (drug therapy, etiology, surgery)
  • Flucytosine (therapeutic use)
  • Heart Valve Prosthesis
  • Humans
  • Male
  • Middle Aged

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