Cytotoxic and mutagenic effects of carcinogenic aromatic amides and polycyclic hydrocarbons and ultraviolet irradiation in normally repairing and repair-deficient (xeroderma pigmentosum) diploid human skin fibroblasts.

Abstract

The cloning ability of fibroblasts taken from a xeroderma pigmentosum patient proved 2.5-3.5 times more sensitive to the cytotoxic effect of active derivatives of carcinogens or to UV irradiation than that of normal cells. They also exhibited a corresponding 2.5- to 2.5-fold greater increase in the frequency of induced mutations to 8-azaguanine resistance per survivor, which might have been expected since these XP cells exhibit less than 20% of the DNA-repairing capacity of the normal cells following exposure to such DNA-damaging agents.

• Authors: V M Maher, J J McCormick
• Journal: Basic life sciences (Basic Life Sci) Vol. 5B Pg. 785-7 ( 1975) ISSN: 0090-5542 [Print] United States
• PMID: 1191198 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Amides
• Carcinogens
• Polycyclic Compounds

Topics

• Amides (pharmacology)
• Carcinogens (pharmacology)
• Cell Survival (radiation effects)
• Diploidy
• Fibroblasts (drug effects, metabolism, radiation effects)
• Polycyclic Compounds (pharmacology)
• Radiation Effects
• Skin (drug effects, metabolism, radiation effects)
• Ultraviolet Rays
• Xeroderma Pigmentosum (metabolism)