Abstract | BACKGROUND & AIMS: METHODS: Twelve naturally infected sheep were selected and divided into 2 subgroups: treatment group (n = 9) and control group (n = 3). In the treatment group, approximate volume of ivermectin solution needed to achieve an intracystic concentration of 10 microg/mL was injected into cysts, but in the control group, sterile distillated water was applied. No reaspiration was performed at all. RESULTS: In the following period of 6 months, repeated sonography revealed a significant decrease in cyst sizes and progressive solidification of the cysts in the treatment group. In the control group, volumes of the cysts were increased. No major complications occurred during or after the procedure. After 6 months, all sheep were killed and examined for macroscopic and microscopic changes. Pathologic examination in the treatment group showed pericyst hyalinization, inflammatory cells in the cyst wall, degeneration of laminated and germinal membrane, and necrotic material in the cyst cavity. No viable protoscolices or daughter cysts were observed. CONCLUSIONS:
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Authors | Murat Hokelek, Bekir Ahmet Deger, Emin Deger, Ediz Tutar, Mustafa Sunbul |
Journal | Gastroenterology
(Gastroenterology)
Vol. 122
Issue 4
Pg. 957-62
(Apr 2002)
ISSN: 0016-5085 [Print] United States |
PMID | 11910348
(Publication Type: Journal Article)
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Chemical References |
- Antiprotozoal Agents
- Ivermectin
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Topics |
- Administration, Cutaneous
- Animals
- Antiprotozoal Agents
(pharmacology)
- Disease Models, Animal
- Echinococcosis
(diagnostic imaging, drug therapy)
- Ivermectin
(pharmacology)
- Sheep
- Ultrasonography
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