Abstract | BACKGROUND: OBJECTIVE: METHODS: RESULTS: Systolic blood pressure was reduced after quinapril treatment. Tranilast did not alter blood pressure (2K1C: 223 +/- 19 mmHg; 2K1C + quinapril: 149 +/- 15 mmHg (P < 0.01 compared with 2K1C); 2K1C + tranilast: 204 +/- 32 mmHg). Left ventricular weight was likewise reduced significantly by quinapril, but not significantly by tranilast (2K1C: 1.52 +/- 0.2 g; 2K1C + quinapril: 1.26 +/- 0.18 g (P < 0.05 compared with 2K1C); 2K1C + tranilast: 1.37 +/- 0.27 g). Using a computer-aided image analysis system, we demonstrated that tranilast prevented cardiac fibrosis in a blood-pressure-independent manner (P < 0.01 compared with 2K1C). Determination of the cardiac hydroxyproline content similarly revealed a significant reduction in cardiac fibrosis by tranilast (2K1C: 4.92 +/- 0.48 mg/mg; 2K1C + tranilast: 3.97 +/- 0.46 mg/mg; P < 0.05). The effect of tranilast on cardiac fibrosis was comparable to the effects of a blood-pressure-decreasing dose of the ACE inhibitor, quinapril. Cell culture experiments revealed that tranilast significantly decreased the proliferation of cardiac non-myocyte cells. Proliferation of cardiac myocytes was not altered. CONCLUSION:
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Authors | Berthold Hocher, Michael Godes, Jan Olivier, Joachim Weil, Thomas Eschenhagen, Torsten Slowinski, Hans-H Neumayer, Christian Bauer, Martin Paul, Yigal M Pinto |
Journal | Journal of hypertension
(J Hypertens)
Vol. 20
Issue 4
Pg. 745-51
(Apr 2002)
ISSN: 0263-6352 [Print] England |
PMID | 11910312
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Isoquinolines
- Tetrahydroisoquinolines
- Transforming Growth Factor beta
- ortho-Aminobenzoates
- tranilast
- Quinapril
- Hydroxyproline
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Topics |
- Angiotensin-Converting Enzyme Inhibitors
(therapeutic use)
- Animals
- Blood Pressure
(drug effects)
- Cell Division
(drug effects)
- Fibrosis
- Heart Ventricles
(drug effects, pathology)
- Hydroxyproline
(metabolism)
- Hypertension, Renovascular
(drug therapy, pathology, physiopathology)
- In Vitro Techniques
- Isoquinolines
(therapeutic use)
- Male
- Myocardium
(metabolism, pathology)
- Quinapril
- Rats
- Rats, Inbred WKY
- Tetrahydroisoquinolines
- Transforming Growth Factor beta
(antagonists & inhibitors)
- Ventricular Remodeling
(drug effects)
- ortho-Aminobenzoates
(therapeutic use)
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