Prevention of experimental autoimmune cardiomyopathy in rabbits by receptor blockers.

Abstract

We investigated the effects of beta1-adrenoceptor blockade and M2-muscarinic receptor antagonist in rabbits which have developed dilated cardiomyopathy-like changes after immunization with the peptides from the second extracellular loop of human beta1-adrenoceptor (beta1-peptide) and M2-muscarinic receptor (M2-peptide). Ten rabbits, which were immunized with beta1-peptide once a month for one year, were treated with bisoprolol and 10 rabbits, which were immunized with M2-peptide, were treated with otenzepad. Although both groups treated with receptor blockade or antagonist showed an increased titer of anti-beta1-adrenoceptor or anti-M2-muscarinic receptor antibodies, myocardial damages were markedly less than those in beta1-peptide- or M2-peptide-immunized rabbits. This study indicates that anti-beta1-adrenoceptor and anti-M2-muscarinic receptor antibodies are of pathogenic importance in the development of human dilated cardiomyopathy, and that beta-adrenoceptor blockade, bisoprolol, and M2-muscarinic receptor antagonist, otenzepad, might be clinically useful for treatment of dilated cardiomyopathy.

• Authors: S Matsui, M L Fu
• Journal: Autoimmunity (Autoimmunity) Vol. 34 Issue 3 Pg. 217-20 ( 2001) ISSN: 0891-6934 [Print] England
• PMID: 11908781 (Publication Type: Journal Article)

Chemical References

• Adrenergic beta-1 Receptor Antagonists
• Adrenergic beta-Antagonists
• Muscarinic Antagonists
• Receptors, Adrenergic, beta-1
• Receptors, Muscarinic
• Pirenzepine
• otenzepad
• Bisoprolol

Topics

• Adrenergic beta-1 Receptor Antagonists
• Adrenergic beta-Antagonists (pharmacology)
• Animals
• Autoimmune Diseases (immunology, prevention & control)
• Bisoprolol (pharmacology)
• Cardiomyopathies (immunology, prevention & control)
• Disease Models, Animal
• Muscarinic Antagonists (pharmacology)
• Pirenzepine (analogs & derivatives, pharmacology)
• Rabbits
• Receptors, Adrenergic, beta-1 (immunology)
• Receptors, Muscarinic (immunology)