Abstract |
Topical application of 9-beta-d-arabinofuranosylhypoxanthine 5'-monophosphate ( ara-HxMP) significantly inhibited the development of keratitis induced by types 1 and 2 herpes simplex virus and vaccinia virus in the eyes of rabbits. Parameters for evaluation of efficacy were infectivity ( corneal opacity, lesion size, and type), Draize ( erythema, conjunctival swelling, and discharge), and reduction in titer of recoverable virus from the eye. When the relative efficacy of the related compounds 9-beta-d-arabinofuranosyladenine ( ara-A), ara-A 5'-monophosphate ( ara-AMP), and ara-Hx was determined against type 1 herpes simplex virus in a parallel experiment, the more water-soluble compounds ( ara-HxMP, ara-AMP) were the most effective. The relative efficacy of ara-A was also determined against type 2 herpes and vaccinia virus-induced keratitis. Mortality in rabbits due to central nervous system involvement caused by types 1 and 2 herpes simplex virus was inhibited. Ara-HxMP was not discernibly toxic to the eye at concentrations of at least 20%; efficacy was still discernible with a 0.1% solution.
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Authors | R W Sidwell, L B Allen, J H Huffman, G R Revankar, R K Robins, R L Tolman |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 8
Issue 4
Pg. 463-7
(Oct 1975)
ISSN: 0066-4804 [Print] United States |
PMID | 1190753
(Publication Type: Journal Article)
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Chemical References |
- Antiviral Agents
- Inosine Nucleotides
- Inosine Monophosphate
- Arabinose
- Vidarabine
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Topics |
- Animals
- Antiviral Agents
(therapeutic use)
- Arabinose
(analogs & derivatives, therapeutic use)
- Female
- Inosine Monophosphate
(therapeutic use)
- Inosine Nucleotides
(therapeutic use)
- Keratitis
(drug therapy)
- Keratitis, Dendritic
(drug therapy)
- Rabbits
- Time Factors
- Vaccinia
(drug therapy)
- Vidarabine
(therapeutic use)
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