Fatal diffuse alveolar damage complicating acute myeloid leukemia with abnormal eosinophils and trisomy X.

Abstract

We describe a case of acute myeloid leukemia (AML) with abnormal eosinophils in a 44-year-old Chinese woman that was complicated by diffuse alveolar damage (DAD) and pulmonary hemorrhage (PH) shortly after induction chemotherapy. Cytogenetic study of bone marrow cells at diagnosis showed a rare aberration of trisomy X (+X) as the sole acquired karyotypic abnormality. We speculate that tissue damage by cellular constituents of the abnormal eosinophils that were released on cell lysis after chemotherapy might be etiologically linked to the occurrence of fatal pulmonary complications.

• Authors: T S K Wan, S F Yip, Y M Yeung, L C Chan, S K Ma
• Journal: Annals of hematology (Ann Hematol) Vol. 81 Issue 3 Pg. 167-9 (Mar 2002) ISSN: 0939-5555 [Print] Germany
• PMID: 11904745 (Publication Type: Case Reports, Journal Article, Review)

Topics

• Acute Disease
• Adult
• Eosinophils (pathology)
• Fatal Outcome
• Female
• Hemorrhage (complications)
• Humans
• Leukemia, Myeloid (complications, genetics, pathology)
• Lung Diseases (complications)
• Pulmonary Alveoli (pathology)
• Trisomy (genetics)
• X Chromosome (genetics)