Abstract |
Enrasentan is an antagonist of endothelin (ET) receptors. Previous studies have shown that antagonism of ET receptors might represent a new approach to the treatment of hypertension. Rats with a high- fructose diet (HFD) develop hyperinsulinemia, hypertriglyceridemia, and hypertension; renal and cardiac damage. The aim of this study was to evaluate whether enrasentan could reverse the hypertension and reduce the target organ damage induced by an HFD. Fifty-five WKY rats were divided into 6 groups; 35 animals received HFD for a month; thereafter 5 animals were killed, and the others were treated either with enrasentan (n = 10), hydralazine (n = 10), or placebo (n = 10) for a further month while on the HFD. Twenty animals were kept on a standard diet throughout the study; either placebo (n = 10) or enrasentan (n = 10) was administered during the second month. Enrasentan and hydralazine completely eliminated the HFD-induced increase in blood pressure; however, only enrasentan reduced the renal and cardiac damage caused by the diet. In conclusion, enrasentan was effective both in normalizing blood pressure and in reducing renal and cardiac damage; the organ protection cannot be attributed solely to the antihypertensive effect, because it was absent in the case of hydralazine, despite successful control of blood pressure.
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Authors | Alessandro Cosenzi, E Bernobich, M Bonavita, G Bertola, R Trevisan, G Bellini |
Journal | Journal of cardiovascular pharmacology
(J Cardiovasc Pharmacol)
Vol. 39
Issue 4
Pg. 488-95
(Apr 2002)
ISSN: 0160-2446 [Print] United States |
PMID | 11904522
(Publication Type: Journal Article)
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Chemical References |
- Carboxylic Acids
- Dietary Carbohydrates
- Endothelin Receptor Antagonists
- Indans
- Fructose
- Collagen
- enrasentan
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Topics |
- Animals
- Blood Pressure
(drug effects)
- Body Weight
(drug effects)
- Carboxylic Acids
(therapeutic use)
- Collagen
(metabolism)
- Dietary Carbohydrates
(administration & dosage)
- Disease Models, Animal
- Endothelin Receptor Antagonists
- Fructose
(administration & dosage)
- Hyperinsulinism
(chemically induced, complications, drug therapy, physiopathology)
- Hypertension
(chemically induced, complications, drug therapy, physiopathology)
- Indans
(therapeutic use)
- Kidney
(drug effects, metabolism, pathology)
- Male
- Myocardium
(metabolism, pathology)
- Rats
- Rats, Inbred WKY
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