Abstract | PURPOSE: Several studies have evaluated the efficacy of the recombinant colony-stimulating factors in reducing the severity and duration of neutropenia and the risk of infection associated with dose-intensive cancer chemotherapy. We performed a meta-analysis to define better the magnitude of this effect and to assess the generalizability of the results among different diseases and types of treatment. MATERIALS AND METHODS: RESULTS: CONCLUSION:
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Authors | Gary H Lyman, Nicole M Kuderer, Benjamin Djulbegovic |
Journal | The American journal of medicine
(Am J Med)
Vol. 112
Issue 5
Pg. 406-11
(Apr 01 2002)
ISSN: 0002-9343 [Print] United States |
PMID | 11904116
(Publication Type: Journal Article, Meta-Analysis)
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Chemical References |
- Antineoplastic Agents
- Recombinant Proteins
- Granulocyte Colony-Stimulating Factor
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Topics |
- Antineoplastic Agents
(adverse effects)
- Dose-Response Relationship, Drug
- Granulocyte Colony-Stimulating Factor
(therapeutic use)
- Humans
- Neoplasms
(drug therapy)
- Neutropenia
(drug therapy, etiology, prevention & control)
- Randomized Controlled Trials as Topic
- Recombinant Proteins
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