Preoperative oral granisetron for the prevention of vomiting following paediatric surgery.

Abstract

BACKGROUND:

We evaluated the efficacy of granisetron, 5-hydroxytryptamine type 3 receptor antagonist, given orally, preoperatively, for the prevention of postoperative vomiting in children undergoing general anaesthesia for surgery (inguinal hernia, phimosis-circumcision).

METHODS:

In a randomized, double-blinded manner, 100 children, ASA physical status I, aged 4-11 years, received orally placebo or granisetron at three different doses (20 microg x kg(-1), 40 microg x kg(-1), 80 microg x kg(-1)) 60 min before surgery (n=25 of each). The same standard general anaesthetic technique was used.

RESULTS:

The percentage of patients being emesis-free during 0-6 h after anaesthesia was 56% with placebo, 64% with graniseron 20 microg x kg(-1) (P=0.773), 88% with granisetron 40 microg x kg(-1) (P=0.027) and 92% with granisetron 80 microg x kg(-1) (P=0.01); the corresponding rate during 6-24 h after anaesthesia was 60%, 68% (P=0.768), 92% (P=0.02) and 92% (P=0.02) (P-values versus placebo). No clinically serious adverse events were observed in any of the groups.

CONCLUSIONS:

In summary, preoperative oral granisetron 40 microg x kg(-1) is effective for the prevention of vomiting following paediatric surgery (inguinal hernia, phimosis-circumcision). Increasing the doses to 80 microg x kg(-1) provides no demonstrable additional benefit.

• Authors: Yoshitaka Fujii, Hiritoshi Tanaka
• Journal: Paediatric anaesthesia (Paediatr Anaesth) Vol. 12 Issue 3 Pg. 267-71 (Mar 2002) ISSN: 1155-5645 [Print] France
• PMID: 11903942 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Retracted Publication)

Chemical References

• Antiemetics
• Granisetron

Topics

• Administration, Oral
• Anesthesia, General
• Antiemetics (administration & dosage, therapeutic use)
• Child
• Child, Preschool
• Circumcision, Male
• Double-Blind Method
• Female
• Granisetron (administration & dosage, therapeutic use)
• Hernia, Inguinal (surgery)
• Humans
• Male
• Phimosis (surgery)
• Postoperative Nausea and Vomiting (prevention & control)
• Preoperative Care
• Prospective Studies