Abstract | BACKGROUND: METHODS: The subjects consisted of six patients with stage III nasopharyngeal cancer and 26 patients with stage IV nasopharyngeal cancer. Using 6 MV photons, radiotherapy was performed at an exposure of 1.8-2.0 Gy five times per week. That is, a total absorbed dose of 36-40 Gy was irradiated between the base of the skull and supraclavicular fossa. After decreasing the irradiation field, an absorbed dose of 26-30 Gy was additionally given thereafter. One course of chemotherapy consisted of the administration of 5-fluorouracil (5-FU) at a dose of 700 mg/m2/24 h for 5 days (days 1-5) and cisplatin (CDDP) at a dose of 50 mg/m2/24 h for 2 days (days 6-7) and a total of 2-3 courses of chemotherapy were performed. During the alternating chemoradiotherapy, chemotherapy was performed initially and 3-5 days after completing the chemotherapy, radiotherapy was performed for 3-4 weeks. Thereafter, chemotherapy and radiotherapy were performed alternately. RESULTS: The scheduled courses of alternating chemoradiotherapy were completed in 30 (94%) of 32 patients. Although one patient developed shock induced by metal allergy to CDDP, no severe adverse effects were noted in any other patients. In these 32 patients, the overall 5-year survival rate was 75% (95% confidence interval: 60-90%) and the progression-free survival rate was 63% (95% CI: 46-89%). CONCLUSIONS:
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Authors | N Fuwa, Y Ito, T Kodaira, A Matsumoto, M Kamata, K Furutani, H Tatibana, M Sasaoka, K Morita |
Journal | Japanese journal of clinical oncology
(Jpn J Clin Oncol)
Vol. 31
Issue 12
Pg. 589-95
(Dec 2001)
ISSN: 0368-2811 [Print] England |
PMID | 11902489
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, therapeutic use)
- Cisplatin
(administration & dosage)
- Combined Modality Therapy
- Drug Administration Schedule
- Female
- Fluorouracil
(administration & dosage)
- Humans
- Male
- Middle Aged
- Nasopharyngeal Neoplasms
(drug therapy, mortality, radiotherapy)
- Radiotherapy Dosage
- Survival Rate
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