Abstract | BACKGROUND: METHODS AND RESULTS: This was a randomized, double-blind, ascending-dose, crossover study evaluating 3 doses of BG9719 in 63 patients with congestive heart failure. Patients received placebo or 1 of 3 doses of BG9719 on 1 day and the same medication plus furosemide on a separate day. Renal function and electrolyte and water excretion were assessed. BG9719 alone caused an increase in urine output and sodium excretion (P<0.05). Although administration of furosemide alone caused a large diuresis, addition of BG9719 to furosemide increased diuresis, which was significant at the 0.75-microg/mL concentration. BG9719 alone improved glomerular filtration rate (GFR) at the 2 lower doses. Furosemide alone caused a decline in GFR. When BG9719 was added to furosemide, however, creatinine clearance remained at baseline at the 2 lower doses. CONCLUSIONS:
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Authors | Stephen S Gottlieb, D Craig Brater, Ignatius Thomas, Edward Havranek, Robert Bourge, Steven Goldman, Farere Dyer, Miguel Gomez, Donald Bennett, Barry Ticho, Evan Beckman, William T Abraham |
Journal | Circulation
(Circulation)
Vol. 105
Issue 11
Pg. 1348-53
(Mar 19 2002)
ISSN: 1524-4539 [Electronic] United States |
PMID | 11901047
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- 1,3-dipropyl-8-(2-(5,6-epoxy)norbornyl)xanthine
- Angiotensin-Converting Enzyme Inhibitors
- Diuretics
- Drug Combinations
- Electrolytes
- Purinergic P1 Receptor Antagonists
- Xanthines
- Furosemide
- Sodium
- Creatinine
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Topics |
- Aged
- Angiotensin-Converting Enzyme Inhibitors
(pharmacology)
- Blood Pressure
(drug effects)
- Creatinine
(blood, urine)
- Cross-Over Studies
- Diuresis
(drug effects)
- Diuretics
(adverse effects, therapeutic use)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Drug Combinations
- Electrolytes
(urine)
- Female
- Furosemide
(adverse effects, therapeutic use)
- Glomerular Filtration Rate
(drug effects)
- Heart Failure
(drug therapy)
- Heart Rate
(drug effects)
- Humans
- Male
- Middle Aged
- Purinergic P1 Receptor Antagonists
- Sodium
(urine)
- Urinalysis
- Xanthines
(blood, therapeutic use)
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