Growth hormone and insulin-like growth factor-I in symptomatic and asymptomatic patients with diffuse idiopathic skeletal hyperostosis (DISH).

Abstract

Basal serum growth hormone (GH) and insulin-like growth factor-I (IGF-I) concentration was measured by radioimmunoassay in patients with diffuse idiopathic skeletal hyperostosis (DISH) with muscle and joint pain and stiffness (symptomatic group) and in DISH patients without these constitutional clinical symptoms (asymptomatic group), but with persistent radiographic evidence of DISH. Serum GH and IGF-I was also measured in normal volunteers (control group) matched for gender and age to patients with DISH. Symptomatic male and female DISH patients had elevated serum GH and IGF-I concentration when compared to the control group. Asymptomatic DISH patients had serum GH levels that were significantly lower than their symptomatic counterparts. Clinical improvement did not alter serum IGF-I concentration. We conclude that serum GH concentration could be employed to monitor clinical remission in DISH.

• Authors: Charles W Denko, Betty Boja, Charles J Malemud
• Journal: Frontiers in bioscience : a journal and virtual library (Front Biosci) Vol. 7 Pg. a37-43 (Apr 01 2002) ISSN: 1093-9946 [Print] United States
• PMID: 11897552 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Human Growth Hormone
• Insulin-Like Growth Factor I

Topics

• Exostoses (diagnostic imaging)
• Female
• Human Growth Hormone (blood)
• Humans
• Hyperostosis, Diffuse Idiopathic Skeletal (blood, diagnosis, diagnostic imaging)
• Insulin-Like Growth Factor I (analysis)
• Male
• Middle Aged
• Pain (diagnosis)
• Radiography