Abstract |
The objective of this study was to analyse the influence of the composition of the core of the pellets on the in vitro drug release profile. The different materials (drugs and fillers) were chosen according to their relative solubility. Pellets were prepared by a standardised process of extrusion/spheronisation. A selected fraction size (1-1.4 mm diameter) of pellets of each preparation was coated with Surelease (an aqueous dispersion of ethyl cellulose) to give 5% weight gain. The dissolution studies were performed and data analysed in terms of the Area under the Curve (AUC) of the % dissolved as function of time and Mean Dissolution Time (MDT). ANOVA was applied in order to identify the influence factors and the relationship of cross effects. Canonical analysis and multiple regression were employed to quantify these relationships. The film coat was found to be the major factor controlling the drug release. The results however, show that both drug and filler solubility influenced the drug release profile. Some of the unusual results could only be explained if consideration was given to the physical characteristics of both powder and pellets. In particular, the specific surface area of calcium phosphate compared with other fillers played an important role on the release profile of the model drug.
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Authors | J J Sousa, A Sousa, M J Moura, F Podczeck, J M Newton |
Journal | International journal of pharmaceutics
(Int J Pharm)
Vol. 233
Issue 1-2
Pg. 111-22
(Feb 21 2002)
ISSN: 0378-5173 [Print] Netherlands |
PMID | 11897415
(Publication Type: Journal Article)
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Chemical References |
- Drug Implants
- Tablets, Enteric-Coated
- ethyl cellulose
- Cellulose
- Propranolol
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Topics |
- Cellulose
(analogs & derivatives, chemistry, pharmacokinetics)
- Chemistry, Pharmaceutical
(statistics & numerical data)
- Drug Implants
(chemistry, pharmacokinetics)
- Porosity
- Propranolol
(pharmacokinetics)
- Solubility
- Tablets, Enteric-Coated
(chemistry, pharmacokinetics)
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